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Image Search Results
Journal: Biology
Article Title: Induction of Reactive Bone Stromal Fibroblasts in 3D Models of Prostate Cancer Bone Metastases
doi: 10.3390/biology12060861
Figure Lengend Snippet: Alteration in the transcriptomic signatures of HS5-PC3 cells ( A ) Microarray principal analysis of HS5 control (yellow n = 3), PC3 (blue n = 4), HS5-PC3 (green n = 4), co-culture (PC3 + HS5: red n = 6) and PC3 cells conditioned with HS5 media (purple n = 3). ( B ) FEN diagram outlining 15 gene alterations in HS5-PC3 cells. ( C ) FEN diagram outlining alterations in over 98 genes when PC3 cells are treated with HS5 conditioned media, with the 10 most significant gene alterations listed. Genes highlighted in yellow have been reported previously in other cancer progressions and/or reported as potential pharmaceutical targets in advanced cancers.
Article Snippet: Four biological repeats of each cell culture type were collected and ran on an
Techniques: Microarray, Co-Culture Assay